Peptidyl-lysine monomethylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-lysine monomethylation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BHLHE41, DEDD, and UGP2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-lysine monomethylation activity versus BHLHE41 in LSCC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BHLHE41 →	-0.692	-0.514	<.001	.005	3	3
UCEC	DEDD →	+0.313	+0.427	.008	.005	3	3
GBM	UGP2 →	-0.333	-0.526	<.001	.001	3	3
GBM	HNRNPA1P66 →	-0.312	-0.493	.001	.003	3	3
GBM	HPF1 →	-0.366	-0.691	<.001	<.001	3	3
PDAC	NBDY →	-0.181	-0.275	.009	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018026 vs BHLHE41 — LSCC

Explore this scatter interactively →