Peptidyl-lysine monomethylation

Across TCGA cell cohorts, RNA activity of the Peptidyl-lysine monomethylation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMOD2, MAGED2, and HNRNPA0, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMOD2 grouped by Peptidyl-lysine monomethylation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TMOD2 →	-1.867	-0.450	.003	.003	3	4
BREAST	MAGED2 →	-1.490	-1.016	.001	<.001	3	4
LIVER	HNRNPA0 →	+0.590	+1.224	.003	.001	3	3
LIVER	ANKRD34A →	-0.820	-0.908	.005	.003	3	3
LIVER	FAM50A →	-0.928	-1.231	.004	.001	3	3
SOFT_TISSUE	CATSPER3 →	-0.319	-1.281	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMOD2 by Peptidyl-lysine monomethylation activity — URINARY_TRACT

Explore this box plot interactively →