Peptidyl-lysine trimethylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-lysine trimethylation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCGR1A, RAB3IL1, and GPSM2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-lysine trimethylation activity versus FCGR1A in GBM (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FCGR1A →	-0.725	-0.254	<.001	<.001	3	4
HNSC	RAB3IL1 →	-0.534	-0.565	.002	<.001	3	4
GBM	GPSM2 →	+0.659	+0.239	<.001	<.001	3	4
GBM	CD86 →	-0.736	-0.228	<.001	<.001	3	3
GBM	ALOX5AP →	-1.017	-0.204	<.001	.001	3	3
GBM	GYPC →	-0.787	-0.234	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018023 vs FCGR1A — GBM

Explore this scatter interactively →