Peptidyl-lysine trimethylation

Across TCGA cell cohorts, RNA activity of the Peptidyl-lysine trimethylation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCND1, IFT57, and MPDZ, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCND1 grouped by Peptidyl-lysine trimethylation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	KCND1 →	-1.033	-0.142	.001	.008	3	4
SKIN	IFT57 →	-0.643	-0.098	.001	.004	3	4
LUNG_NSCLC_LUSC	MPDZ →	-1.258	-0.184	.003	.006	3	3
LUNG_NSCLC_LUSC	PEX12 →	-0.998	-0.190	.008	.003	3	3
LUNG_NSCLC_LUSC	APBB3 →	-1.668	-0.173	<.001	.006	3	3
STOMACH	EEF1B2 →	+0.958	+0.159	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCND1 by Peptidyl-lysine trimethylation activity — LIVER

Explore this box plot interactively →