Peptidyl-lysine trimethylation

Across TCGA cell cohorts, RNA activity of the Peptidyl-lysine trimethylation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ESYT2, FUT6, and GPR151, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ESYT2 grouped by Peptidyl-lysine trimethylation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ESYT2 →	-0.254	-0.161	.001	.008	3	3
LUNG_NSCLC_LUAD	FUT6 →	+0.196	+0.213	.009	.005	2	4
CNS	GPR151 →	-0.235	-0.165	.003	.005	3	3
STOMACH	CHURC1-FNTB →	-0.247	-0.246	.004	.009	3	3
LUNG_SCLC	PPIP5K1 →	+0.355	+0.128	.004	.004	3	3
SKIN	CHD8 →	+0.370	+0.201	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ESYT2 by Peptidyl-lysine trimethylation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →