Peptidyl-lysine methylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-lysine methylation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HNRNPU, SMC1A, and VPS72, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-lysine methylation activity versus HNRNPU in GBM (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HNRNPU →	+0.244	+0.033	.001	.002	3	7
GBM	SMC1A →	+0.410	+0.041	<.001	<.001	3	6
GBM	VPS72 →	+0.400	+0.039	.008	<.001	3	6
GBM	WDR5 →	+0.322	+0.033	.001	.005	3	6
HNSC	XPO1 →	+0.218	+0.063	.002	<.001	3	6
GBM	CXXC1 →	+0.207	+0.030	.004	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018022 vs HNRNPU — GBM

Explore this scatter interactively →