Peptidyl-lysine methylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-lysine methylation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIN9, EZH2, and HELLS, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-lysine methylation activity versus LIN9 in OV (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LIN9 →	+0.518	+0.290	.002	<.001	3	7
HNSC	EZH2 →	+0.762	+0.336	.004	.003	3	7
LSCC	HELLS →	+0.764	+0.473	<.001	<.001	3	7
GBM	KIFC1 →	+1.015	+0.592	<.001	<.001	3	7
HNSC	NUF2 →	+0.839	+0.362	.001	<.001	3	6
HNSC	C1orf112 →	+0.576	+0.263	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018022 vs LIN9 — OV

Explore this scatter interactively →