Peptidyl-lysine methylation

Across TCGA cell cohorts, RNA activity of the Peptidyl-lysine methylation pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBX1, IHH, and HEYL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBX1 grouped by Peptidyl-lysine methylation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RBX1 →	+0.443	+0.098	.001	.009	3	5
OESOPHAGUS	IHH →	+0.152	+0.101	.001	.002	2	6
BLOOD_Leukemia	HEYL →	+0.209	+0.067	<.001	<.001	3	5
BREAST	NEUROD4 →	+0.135	+0.070	.005	.009	3	4
BREAST	GTF2H4 →	-0.134	-0.083	.003	.001	3	4
KIDNEY	NPR3 →	-0.144	-0.061	.008	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBX1 by Peptidyl-lysine methylation activity — OESOPHAGUS

Explore this box plot interactively →