Peptidyl-lysine methylation

Across TCGA cell cohorts, RNA activity of the Peptidyl-lysine methylation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNB3, DKK1, and QSOX1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-lysine methylation activity versus CCNB3 in LUNG_NSCLC_LUAD (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CCNB3 →	-0.795	-0.081	.001	.004	3	4
PANCREAS	DKK1 →	+1.994	+0.124	.003	.004	3	3
UPPER_AERODIGESTIVE_TRACT	QSOX1 →	+1.504	+0.131	<.001	.009	3	3
UPPER_AERODIGESTIVE_TRACT	PLK2 →	+1.293	+0.124	.001	<.001	3	3
OESOPHAGUS	ITGAL →	+0.179	+0.125	<.001	.009	3	3
LARGE_INTESTINE	SLC1A5 →	-1.256	-0.703	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018022 vs CCNB3 — LUNG_NSCLC_LUAD

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