Peptidyl-lysine hydroxylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-lysine hydroxylation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FKBP10, LOX, and SEC23A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-lysine hydroxylation activity versus FKBP10 in GBM (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FKBP10 →	+0.441	+0.129	.001	<.001	3	7
GBM	LOX →	+1.470	+0.239	<.001	<.001	3	6
PDAC	SEC23A →	+0.404	+0.125	<.001	<.001	3	6
OV	RCN3 →	+1.292	+0.145	<.001	<.001	3	6
OV	CTHRC1 →	+1.737	+0.181	<.001	<.001	3	6
OV	IKBIP →	+0.541	+0.136	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017185 vs FKBP10 — GBM

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