Peptidyl-lysine hydroxylation

Across TCGA cell cohorts, RNA activity of the Peptidyl-lysine hydroxylation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLK3, BCDIN3D, and RPL6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-lysine hydroxylation activity versus CLK3 in BLOOD_Leukemia (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CLK3 →	-0.541	-0.419	<.001	<.001	3	4
SOFT_TISSUE	BCDIN3D →	-0.789	-1.707	.007	<.001	2	4
SOFT_TISSUE	RPL6 →	+0.359	+1.401	.003	.008	3	3
CNS	LUM →	+2.832	+1.150	.009	<.001	3	3
BREAST	TRMT11 →	+0.761	+1.370	.008	.007	3	3
STOMACH	ADAT2 →	+0.982	+0.845	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017185 vs CLK3 — BLOOD_Leukemia

Explore this scatter interactively →