Protein histidyl modification to diphthamide

Across TCGA patient cohorts, RNA activity of the Protein histidyl modification to diphthamide pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BEAN1-AS1, CDC26P1, and HSPB8, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein histidyl modification to diphthamide activity versus BEAN1-AS1 in UCEC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BEAN1-AS1 →	-0.659	-0.608	<.001	.002	3	3
BRCA	CDC26P1 →	+0.686	+0.891	<.001	<.001	3	3
OV	HSPB8 →	-0.645	-0.430	.005	.004	3	3
UCEC	TRBV23-1 →	-0.944	-0.552	.006	<.001	3	2
UCEC	HMGN2P8 →	+1.127	+0.424	.008	.001	3	2
GBM	NICN2P →	-0.135	-0.124	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017183 vs BEAN1-AS1 — UCEC

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