Regulation of calcium ion-dependent exocytosis

Across TCGA patient cohorts, RNA activity of the Regulation of calcium ion-dependent exocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYT7, TBC1D2B, and EHBP1L1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcium ion-dependent exocytosis activity versus SYT7 in GBM (Pearson r = 0.69).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SYT7 →	+1.027	+0.073	<.001	<.001	3	7
GBM	TBC1D2B →	-0.344	-0.063	<.001	<.001	3	6
GBM	EHBP1L1 →	-0.375	-0.059	<.001	<.001	3	5
GBM	CAMSAP3 →	+0.680	+0.087	<.001	<.001	3	5
BRCA	SYT1 →	+0.862	+0.032	.002	.005	3	5
BRCA	ADPGK →	-0.206	-0.030	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017158 vs SYT7 — GBM

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