Regulation of calcium ion-dependent exocytosis

Across TCGA cell cohorts, RNA activity of the Regulation of calcium ion-dependent exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNAI2, IQGAP1, and CYLD, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcium ion-dependent exocytosis activity versus GNAI2 in LARGE_INTESTINE (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GNAI2 →	+1.322	+1.246	.001	<.001	3	10
LIVER	IQGAP1 →	+1.179	+1.323	<.001	.002	3	5
LIVER	CYLD →	+1.022	+1.408	.009	<.001	2	6
LIVER	PPP1R18 →	+2.295	+1.442	.002	<.001	3	5
OESOPHAGUS	C19orf48 →	-1.057	-0.950	<.001	.003	3	5
LUNG_NSCLC_LUSC	IFI16 →	+2.866	+1.253	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017158 vs GNAI2 — LARGE_INTESTINE

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