Regulation of exocytosis

Across TCGA patient cohorts, RNA activity of the Regulation of exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERPINB9, RASSF5, and SH3YL1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of exocytosis activity versus SERPINB9 in BRCA (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SERPINB9 →	+0.841	+0.303	.002	.001	3	3
BRCA	RASSF5 →	+0.993	+0.236	<.001	<.001	3	3
CCRCC	SH3YL1 →	-0.514	-0.185	.001	.006	3	3
BRCA	IL7R →	+1.215	+0.208	.001	.001	3	3
BRCA	LINC01550 →	+0.305	+0.187	.002	.003	3	3
BRCA	LCP2 →	+0.962	+0.198	.005	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017157 vs SERPINB9 — BRCA

Explore this scatter interactively →