Regulation of exocytosis

Across TCGA cell cohorts, RNA activity of the Regulation of exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C2orf15, HOOK1, and LRFN4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C2orf15 grouped by Regulation of exocytosis-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	C2orf15 →	+1.801	+0.198	.006	.006	2	5
BLOOD_Myeloma	HOOK1 →	+2.392	+0.271	.006	.009	3	4
BLOOD_Myeloma	LRFN4 →	-2.520	-0.294	.002	.003	3	4
LUNG_NSCLC_LUSC	PLA2G12A →	+1.426	+0.183	.004	.005	3	3
KIDNEY	CDC42EP5 →	+0.815	+0.721	<.001	.004	3	3
LUNG_NSCLC_LUSC	TOX3 →	+2.404	+0.200	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C2orf15 by Regulation of exocytosis activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →