Regulation of exocytosis

Across TCGA cell cohorts, RNA activity of the Regulation of exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CATSPER1, SMAD3, and ADRB2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of exocytosis activity versus CATSPER1 in STOMACH (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CATSPER1 →	+1.846	+0.230	<.001	.001	3	8
LIVER	SMAD3 →	+1.252	+0.211	.009	.009	3	8
LIVER	ADRB2 →	+1.692	+0.211	.002	.009	3	8
OESOPHAGUS	F3 →	+3.045	+0.125	<.001	.002	3	7
LIVER	CD274 →	+3.025	+0.274	.002	.004	3	7
LARGE_INTESTINE	ITGA3 →	+2.127	+0.200	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017157 vs CATSPER1 — STOMACH

Explore this scatter interactively →