Regulation of exocytosis

Across TCGA cell cohorts, RNA activity of the Regulation of exocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAB15, RAB5C, and ESYT1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of exocytosis activity versus RAB15 in BONE (Pearson r = 0.66).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RAB15 →	+1.012	+0.212	<.001	<.001	3	12
LARGE_INTESTINE	RAB5C →	+0.876	+0.263	<.001	<.001	3	11
SOFT_TISSUE	ESYT1 →	+1.012	+0.246	<.001	<.001	3	10
SOFT_TISSUE	RAB1B →	+1.122	+0.248	<.001	<.001	3	10
BLOOD_Lymphoma	RHOG →	+1.147	+0.200	<.001	<.001	3	10
SOFT_TISSUE	ATL3 →	+1.978	+0.207	.006	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017157 vs RAB15 — BONE

Explore this scatter interactively →