Calcium-ion regulated exocytosis

Across TCGA patient cohorts, RNA activity of the Calcium-ion regulated exocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYT7, FYB1, and LCP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium-ion regulated exocytosis activity versus SYT7 in GBM (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SYT7 →	+1.002	+0.080	<.001	<.001	3	7
HNSC	FYB1 →	-0.389	-0.034	.007	.007	3	7
HNSC	LCP1 →	-0.590	-0.049	<.001	<.001	3	7
GBM	MYO9B →	-0.256	-0.083	.001	<.001	3	7
BRCA	AIF1 →	-0.416	-0.029	.001	.004	3	6
CCRCC	FERMT3 →	-0.480	-0.052	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017156 vs SYT7 — GBM

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