Calcium-ion regulated exocytosis

Across TCGA cell cohorts, RNA activity of the Calcium-ion regulated exocytosis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS13, PNPLA8, and ABCC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS13 grouped by Calcium-ion regulated exocytosis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RPS13 →	+0.221	+0.788	.001	.008	3	6
LUNG_NSCLC_LUSC	PNPLA8 →	+0.216	+1.643	.001	<.001	3	6
BONE	ABCC2 →	-0.248	-1.231	<.001	.001	2	6
CNS	TMEM130 →	-0.150	-0.505	.001	.008	3	5
PANCREAS	MYH9 →	-0.233	-0.884	.004	.001	3	4
PANCREAS	NT5DC1 →	-0.185	-1.053	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS13 by Calcium-ion regulated exocytosis activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →