Calcium-ion regulated exocytosis

Across TCGA cell cohorts, RNA activity of the Calcium-ion regulated exocytosis pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP3, HMGA2, and OLIG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, USP3 grouped by Calcium-ion regulated exocytosis-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	USP3 →	-0.234	-0.114	.001	.005	3	4
URINARY_TRACT	HMGA2 →	+0.356	+0.166	.006	.004	2	5
BLOOD_Leukemia	OLIG1 →	-0.186	-0.117	.001	.008	3	4
BLOOD_Lymphoma	ZNF43 →	+0.169	+0.204	.001	<.001	3	4
CNS	RIMS4 →	+0.395	+0.124	<.001	.002	3	4
BLOOD_Myeloma	PPIE →	+0.416	+0.064	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

USP3 by Calcium-ion regulated exocytosis activity — BLOOD_Leukemia

Explore this box plot interactively →