Calcium-ion regulated exocytosis

Across TCGA cell cohorts, RNA activity of the Calcium-ion regulated exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLNA, NOMO1, and GPLD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium-ion regulated exocytosis activity versus FLNA in LIVER (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	FLNA →	+2.356	+0.321	.006	.006	3	6
PANCREAS	NOMO1 →	+1.107	+0.255	.003	.002	2	6
BONE	GPLD1 →	-1.208	-0.311	.003	.004	3	5
LIVER	SLC10A3 →	+1.361	+0.346	.002	.001	3	5
CNS	ATP6AP1 →	+1.175	+0.372	<.001	<.001	3	5
BREAST	ACVR2B →	-0.542	-0.245	.009	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017156 vs FLNA — LIVER

Explore this scatter interactively →