Stem cell division

Across TCGA patient cohorts, RNA activity of the Stem cell division pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GSN, VCAN, and VCL_S795, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stem cell division activity versus GSN in BRCA (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GSN →	+0.449	+0.034	<.001	<.001	3	8
CCRCC	VCAN →	+0.825	+0.038	.002	.001	2	9
BRCA	VCL_S795 →	+0.552	+0.040	<.001	<.001	3	8
BRCA	RAB23 →	+0.391	+0.034	<.001	<.001	3	8
COAD	CTHRC1 →	+0.949	+0.050	<.001	<.001	3	7
BRCA	ISLR →	+0.760	+0.037	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017145 vs GSN — BRCA

Explore this scatter interactively →