Stem cell division

Across TCGA patient cohorts, RNA activity of the Stem cell division pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLA, CASS4, and ALOX5AP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stem cell division activity versus SLA in PDAC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SLA →	+0.567	+0.396	<.001	.002	3	4
COAD	CASS4 →	+0.408	+0.412	.005	.007	3	4
LSCC	ALOX5AP →	+0.614	+0.315	<.001	<.001	3	4
HNSC	APCDD1L →	+0.994	+0.407	<.001	.003	3	4
PDAC	CST11 →	-0.084	-0.321	.004	.007	3	4
UCEC	TRBV9 →	+0.706	+0.500	.006	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017145 vs SLA — PDAC

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