Stem cell division

Across TCGA cell cohorts, RNA activity of the Stem cell division pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FUT10, PNPLA6, and CSNK1A1L, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FUT10 grouped by Stem cell division-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FUT10 →	-0.327	-0.590	<.001	.003	3	7
BLOOD_Leukemia	PNPLA6 →	-0.126	-0.443	.006	.008	3	4
OVARY	CSNK1A1L →	-0.126	-0.306	.001	<.001	3	4
BLOOD_Lymphoma	CEACAM4 →	+0.632	+0.399	.001	.002	3	4
BLOOD_Lymphoma	ABR →	+0.469	+0.303	.002	.004	3	4
SOFT_TISSUE	RASGRP2 →	+0.238	+0.310	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FUT10 by Stem cell division activity — SKIN

Explore this box plot interactively →