Stem cell division

Across TCGA cell cohorts, RNA activity of the Stem cell division pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GUCA1B, PCK1, and PTGR2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GUCA1B grouped by Stem cell division-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GUCA1B →	-0.225	-0.302	<.001	<.001	3	4
SKIN	PCK1 →	-0.162	-0.269	<.001	.003	3	3
LUNG_NSCLC_LUSC	PTGR2 →	+0.126	+0.242	.002	.001	3	3
KIDNEY	NPRL2 →	+0.400	+0.386	.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	TRIM22 →	-0.237	-0.452	.005	.001	3	3
STOMACH	SOAT2 →	+0.150	+0.301	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GUCA1B by Stem cell division activity — LIVER

Explore this box plot interactively →