Stem cell division

Across TCGA cell cohorts, RNA activity of the Stem cell division pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPV, SLC39A7, and TADA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stem cell division activity versus CENPV in BREAST (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CENPV →	+1.988	+0.222	.003	<.001	2	5
LUNG_SCLC	SLC39A7 →	-0.498	-0.233	.006	<.001	3	4
LUNG_SCLC	TADA1 →	+0.642	+0.248	<.001	<.001	3	4
SKIN	SLC39A4 →	+1.144	+0.203	.002	.004	3	3
BREAST	EPB41L4A →	-1.269	-0.372	.004	.007	3	3
BREAST	EPN3 →	-1.994	-0.421	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017145 vs CENPV — BREAST

Explore this scatter interactively →