Plasma membrane phospholipid scrambling

Across TCGA patient cohorts, RNA activity of the Plasma membrane phospholipid scrambling pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CASP10, SP100, and INPP5D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Plasma membrane phospholipid scrambling activity versus CASP10 in LSCC (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CASP10 →	+0.351	+0.045	<.001	<.001	3	5
HNSC	SP100 →	+0.437	+0.061	<.001	<.001	3	5
LSCC	INPP5D →	+0.357	+0.040	.006	.005	3	5
LSCC	CD82 →	+0.488	+0.051	.004	.004	3	4
HNSC	SP140 →	+0.560	+0.072	.004	.001	3	4
LSCC	HDAC2 →	-0.244	-0.050	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017121 vs CASP10 — LSCC

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