Plasma membrane phospholipid scrambling

Across TCGA patient cohorts, RNA activity of the Plasma membrane phospholipid scrambling pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HBA2, HBB, and HBA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Plasma membrane phospholipid scrambling activity versus HBA2 in PDAC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HBA2 →	+1.345	+0.579	<.001	<.001	3	6
PDAC	HBB →	+1.465	+0.628	<.001	<.001	3	6
GBM	HBA1 →	+1.267	+0.196	<.001	<.001	3	5
OV	ZFP36 →	+0.909	+0.167	.005	<.001	3	4
OV	CPM →	+1.188	+0.203	.003	.002	3	4
LSCC	MMP25 →	+0.336	+0.251	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017121 vs HBA2 — PDAC

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