Plasma membrane phospholipid scrambling

Across TCGA cell cohorts, RNA activity of the Plasma membrane phospholipid scrambling pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPUSD2, RUVBL2, and ACOT7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPUSD2 grouped by Plasma membrane phospholipid scrambling-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RPUSD2 →	+0.876	+1.607	.005	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	RUVBL2 →	+0.725	+1.188	<.001	.007	3	5
SOFT_TISSUE	ACOT7 →	-1.017	-1.214	.006	.006	3	4
UPPER_AERODIGESTIVE_TRACT	MCM2 →	+1.844	+1.362	<.001	.001	3	4
LUNG_SCLC	SERF1A →	-1.177	-1.127	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	EIF3D →	+0.791	+1.743	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPUSD2 by Plasma membrane phospholipid scrambling activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →