Response to insecticide

Across TCGA patient cohorts, RNA activity of the Response to insecticide pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B_S1208, MAP1B_S1400, and MAP1B_S1427, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to insecticide activity versus MAP1B_S1208 in LSCC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B_S1208 →	+1.010	+0.181	<.001	<.001	3	7
LSCC	MAP1B_S1400 →	+1.136	+0.164	<.001	<.001	3	7
LSCC	MAP1B_S1427 →	+1.823	+0.184	<.001	<.001	3	7
LSCC	MAP1B_S1620 →	+1.399	+0.163	<.001	<.001	3	7
HNSC	MAP1B_S1779 →	+1.257	+0.252	<.001	<.001	3	7
GBM	FECH →	+0.290	+0.092	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017085 vs MAP1B_S1208 — LSCC

Explore this scatter interactively →