Response to insecticide

Across TCGA patient cohorts, RNA activity of the Response to insecticide pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP1B, CMTM3, and OLFML2B, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to insecticide activity versus MAP1B in LSCC (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B →	+2.153	+1.416	<.001	<.001	3	10
BRCA	CMTM3 →	+0.706	+1.152	.001	.001	3	8
BRCA	OLFML2B →	+1.123	+1.275	<.001	<.001	3	7
BRCA	IGFBP7 →	+0.763	+1.449	<.001	<.001	3	7
CCRCC	ARL4C →	+0.917	+0.701	.001	.002	3	7
LSCC	MIR4803 →	+1.891	+1.240	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017085 vs MAP1B — LSCC

Explore this scatter interactively →