Response to insecticide

Across TCGA cell cohorts, RNA activity of the Response to insecticide pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAGK, ZC2HC1A, and SPRY3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NAGK grouped by Response to insecticide-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NAGK →	+0.993	+0.181	.002	.005	3	4
OESOPHAGUS	ZC2HC1A →	+1.267	+0.231	.002	.001	3	4
OESOPHAGUS	SPRY3 →	+0.358	+0.183	.002	.001	3	4
LUNG_NSCLC_LUSC	DYNC1LI2 →	+0.938	+0.153	.002	.007	3	3
LUNG_NSCLC_LUSC	AGAP5 →	+0.781	+0.152	.003	.006	3	3
LUNG_NSCLC_LUSC	SLC26A11 →	+1.196	+0.219	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NAGK by Response to insecticide activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →