Response to insecticide

Across TCGA cell cohorts, RNA activity of the Response to insecticide pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SORBS1, PPP2R1A, and SKP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SORBS1 grouped by Response to insecticide-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SORBS1 →	+0.206	+1.058	.003	.007	3	3
BLOOD_Lymphoma	PPP2R1A →	+0.586	+1.676	.009	<.001	3	3
BLOOD_Lymphoma	SKP1 →	+0.496	+1.676	.001	<.001	3	3
LUNG_NSCLC_LUSC	DNASE2B →	-0.265	-1.912	.003	.005	3	3
LUNG_NSCLC_LUSC	GJA1 →	-0.189	-1.744	<.001	<.001	2	4
LUNG_NSCLC_LUSC	PRSS42P →	-0.255	-1.945	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SORBS1 by Response to insecticide activity — LARGE_INTESTINE

Explore this box plot interactively →