Respiratory chain complex III assembly

Across TCGA patient cohorts, RNA activity of the Respiratory chain complex III assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MRTO4, ACTR3, and CSE1L, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Respiratory chain complex III assembly activity versus MRTO4 in LSCC (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MRTO4 →	+0.320	+0.056	<.001	<.001	3	7
GBM	ACTR3 →	-0.293	-0.065	<.001	<.001	3	7
LSCC	CSE1L →	+0.426	+0.069	<.001	<.001	3	7
LSCC	PPP1R18 →	-0.368	-0.074	<.001	<.001	3	7
LSCC	PTPRE →	-0.290	-0.065	.001	<.001	3	7
BRCA	USP48 →	+0.248	+0.025	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017062 vs MRTO4 — LSCC

Explore this scatter interactively →