Respiratory chain complex III assembly

Across TCGA cell cohorts, RNA activity of the Respiratory chain complex III assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLP2, DUSP4, and ADAM15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLP2 grouped by Respiratory chain complex III assembly-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PLP2 →	+1.403	+1.454	.004	.005	3	4
OVARY	DUSP4 →	+1.758	+1.015	.004	.001	3	4
OVARY	ADAM15 →	+0.999	+1.414	.009	.001	3	4
LARGE_INTESTINE	RMND5A →	-1.101	-1.236	.002	<.001	2	5
BLOOD_Lymphoma	TARS2 →	+1.425	+2.198	.002	<.001	3	3
BLOOD_Lymphoma	PUSL1 →	+0.805	+2.198	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLP2 by Respiratory chain complex III assembly activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →