Respiratory chain complex III assembly

Across TCGA cell cohorts, RNA activity of the Respiratory chain complex III assembly pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CABYR, ST6GAL1, and DYM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Respiratory chain complex III assembly activity versus CABYR in SKIN (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CABYR →	-1.372	-0.980	.003	.009	3	5
OVARY	ST6GAL1 →	+1.704	+0.937	.001	.005	3	5
CNS	DYM →	-0.482	-0.866	<.001	.006	3	4
BLOOD_Myeloma	UCK2 →	-0.937	-1.394	.008	.003	3	4
KIDNEY	NUP210 →	+3.643	+1.309	<.001	.002	3	4
URINARY_TRACT	GJC2 →	-0.534	-1.399	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017062 vs CABYR — SKIN

Explore this scatter interactively →