Protein import

Across TCGA patient cohorts, RNA activity of the Protein import pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBA4A, ING1, and FAM102B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein import activity versus TUBA4A in LSCC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TUBA4A →	+0.399	+0.234	.005	.006	3	3
LSCC	ING1 →	-0.301	-0.279	.004	.001	3	3
LSCC	FAM102B →	-0.339	-0.283	.002	<.001	3	3
LSCC	SIRT1 →	-0.515	-0.251	<.001	.006	3	3
UCEC	MPDZ →	-0.626	-0.255	.008	.008	3	3
UCEC	RNU6-1208P →	-1.185	-0.334	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017038 vs TUBA4A — LSCC

Explore this scatter interactively →