Protein import

Across TCGA cell cohorts, RNA activity of the Protein import pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF135, PLEKHO2, and ERGIC3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF135 grouped by Protein import-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	RNF135 →	-1.290	-1.943	.003	<.001	3	4
BLOOD_Leukemia	PLEKHO2 →	+0.625	+0.844	.001	.009	3	4
LUNG_NSCLC_LUAD	ERGIC3 →	+0.514	+0.588	.004	.004	2	4
LUNG_NSCLC_LUAD	SLC9B1 →	+0.362	+0.834	.001	.001	3	3
LUNG_NSCLC_LUAD	GCFC2 →	+0.572	+0.599	.005	.007	3	3
SKIN	CAB39L →	+0.506	+0.533	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF135 by Protein import activity — BLOOD_Myeloma

Explore this box plot interactively →