Cytochrome complex assembly

Across TCGA patient cohorts, RNA activity of the Cytochrome complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CKAP4_S26, ARPC2, and RUNX1_T14, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytochrome complex assembly activity versus CKAP4_S26 in HNSC (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CKAP4_S26 →	-0.663	-0.069	<.001	.001	3	7
LSCC	ARPC2 →	-0.171	-0.033	<.001	<.001	3	7
OV	RUNX1_T14 →	-1.066	-0.035	<.001	<.001	3	7
GBM	GBP2 →	-0.433	-0.024	.007	.002	3	7
CCRCC	SAMSN1_S347 →	-0.543	-0.020	.003	.006	3	6
LSCC	TNKS1BP1_S1073 →	-0.612	-0.031	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017004 vs CKAP4_S26 — HNSC

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