Cytochrome complex assembly

Across TCGA cell cohorts, RNA activity of the Cytochrome complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTF2, DOC2A, and SRGAP2C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RTF2 grouped by Cytochrome complex assembly-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RTF2 →	-0.685	-1.227	.001	.003	3	5
KIDNEY	DOC2A →	+1.664	+1.102	.003	.007	3	4
LUNG_NSCLC_LUSC	SRGAP2C →	-1.073	-1.705	.004	<.001	3	4
OVARY	CRIP2 →	-2.146	-1.084	.001	<.001	3	4
SOFT_TISSUE	CPPED1 →	-1.550	-1.634	.005	<.001	3	3
SOFT_TISSUE	CCNB3 →	-0.720	-1.628	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RTF2 by Cytochrome complex assembly activity — STOMACH

Explore this box plot interactively →