Cytochrome complex assembly

Across TCGA cell cohorts, RNA activity of the Cytochrome complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1QBP, COX10, and NOP16, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytochrome complex assembly activity versus C1QBP in BLOOD_Myeloma (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	C1QBP →	+1.097	+0.081	.001	.002	3	14
BLOOD_Lymphoma	COX10 →	+0.822	+0.049	.003	.002	3	11
LIVER	NOP16 →	+1.150	+0.070	.001	.005	3	11
BONE	BRIX1 →	+0.909	+0.099	.001	.002	3	11
BLOOD_Leukemia	MRPS12 →	+0.785	+0.064	<.001	<.001	3	11
BLOOD_Myeloma	NHP2 →	+1.098	+0.084	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017004 vs C1QBP — BLOOD_Myeloma

Explore this scatter interactively →