Cytochrome complex assembly

Across TCGA cell cohorts, RNA activity of the Cytochrome complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYNE3, SPATA7, and PITRM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytochrome complex assembly activity versus SYNE3 in LUNG_SCLC (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SYNE3 →	-1.821	-0.951	<.001	<.001	3	5
OESOPHAGUS	SPATA7 →	-0.817	-0.927	.009	.006	2	5
SKIN	PITRM1 →	-0.760	-0.837	<.001	.008	3	4
LARGE_INTESTINE	WDR37 →	-0.487	-1.078	.005	.003	3	4
LUNG_SCLC	STMN1 →	-0.846	-0.851	.001	<.001	3	4
LUNG_NSCLC_LUAD	FAHD1 →	+0.807	+1.315	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017004 vs SYNE3 — LUNG_SCLC

Explore this scatter interactively →