Poly(A)+ mRNA export from nucleus

Across TCGA patient cohorts, RNA activity of the Poly(A)+ mRNA export from nucleus pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PYM1, DNMT3A, and NUP93, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Poly(A)+ mRNA export from nucleus activity versus PYM1 in CCRCC (Pearson r = -0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PYM1 →	-0.132	-0.028	.003	.003	3	5
LSCC	DNMT3A →	+0.598	+0.043	<.001	<.001	3	5
LSCC	NUP93 →	+0.230	+0.046	<.001	<.001	3	5
HNSC	C19orf33_S78 →	-0.852	-0.053	.004	.008	3	5
LSCC	EDC4 →	+0.262	+0.043	<.001	<.001	3	4
BRCA	ACAP1 →	+0.460	+0.034	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016973 vs PYM1 — CCRCC

Explore this scatter interactively →