Poly(A)+ mRNA export from nucleus

Across TCGA cell cohorts, RNA activity of the Poly(A)+ mRNA export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ODF2, EXOSC2, and NUP188, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Poly(A)+ mRNA export from nucleus activity versus ODF2 in PANCREAS (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ODF2 →	+1.137	+0.078	<.001	<.001	3	17
BONE	EXOSC2 →	+1.308	+0.129	<.001	<.001	3	17
OESOPHAGUS	NUP188 →	+1.068	+0.133	<.001	.003	2	17
STOMACH	NUP133 →	+0.825	+0.169	<.001	<.001	3	16
BREAST	DDX19A →	+1.037	+0.099	<.001	<.001	3	16
BONE	GLE1 →	+0.948	+0.137	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016973 vs ODF2 — PANCREAS

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