Poly(A)+ mRNA export from nucleus

Across TCGA cell cohorts, RNA activity of the Poly(A)+ mRNA export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NASP, RAD54L, and PSIP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Poly(A)+ mRNA export from nucleus activity versus NASP in SOFT_TISSUE (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NASP →	+1.202	+0.323	.001	<.001	3	8
BREAST	RAD54L →	+0.988	+0.187	.001	<.001	3	7
LARGE_INTESTINE	PSIP1 →	+0.987	+0.171	<.001	.001	2	7
SOFT_TISSUE	FAM161A →	+1.400	+0.292	.006	.008	2	7
SKIN	FSD1 →	+1.752	+0.189	.001	.008	3	6
SOFT_TISSUE	TAF5 →	+0.986	+0.291	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016973 vs NASP — SOFT_TISSUE

Explore this scatter interactively →