Protein desumoylation

Across TCGA patient cohorts, RNA activity of the Protein desumoylation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC3, EHMT2, and MSH6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein desumoylation activity versus SMC3 in HNSC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SMC3 →	+0.226	+0.071	.003	.006	3	6
GBM	EHMT2 →	+0.207	+0.027	.004	.006	3	6
HNSC	MSH6 →	+0.439	+0.071	.004	.005	3	6
COAD	CEP170 →	+0.239	+0.024	<.001	<.001	3	6
OV	EFTUD2 →	+0.241	+0.043	<.001	.001	3	6
LSCC	PTBP2 →	+1.270	+0.044	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016926 vs SMC3 — HNSC

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