Protein desumoylation

Across TCGA patient cohorts, RNA activity of the Protein desumoylation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS33A, OTUD4P1, and LINC02878, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein desumoylation activity versus VPS33A in LSCC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	VPS33A →	+0.363	+0.389	.001	.007	3	4
HNSC	OTUD4P1 →	+0.652	+0.724	.002	.004	3	4
CCRCC	LINC02878 →	+0.164	+0.135	.006	.001	3	4
CCRCC	DEXI →	+0.318	+0.142	<.001	.008	3	4
CCRCC	HCG25 →	+0.206	+0.157	.009	.004	2	5
UCEC	GNL3L →	+0.401	+0.188	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016926 vs VPS33A — LSCC

Explore this scatter interactively →