Protein desumoylation

Across TCGA cell cohorts, RNA activity of the Protein desumoylation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRP9, STARD5, and JKAMP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RRP9 grouped by Protein desumoylation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RRP9 →	-0.554	-0.219	.002	.007	3	3
BLOOD_Leukemia	STARD5 →	-1.253	-0.336	<.001	.001	3	3
SKIN	JKAMP →	+0.414	+0.464	<.001	.003	3	3
BONE	GDAP2 →	+1.167	+0.276	.004	<.001	3	3
CNS	SFXN2 →	-0.883	-0.252	.001	<.001	3	3
CNS	RPL22L1 →	-1.304	-0.193	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RRP9 by Protein desumoylation activity — BREAST

Explore this box plot interactively →