Protein desumoylation

Across TCGA cell cohorts, RNA activity of the Protein desumoylation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SKP1, VDAC1, and NAXE, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein desumoylation activity versus SKP1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SKP1 →	+0.956	+1.254	.001	<.001	2	6
UPPER_AERODIGESTIVE_TRACT	VDAC1 →	+1.175	+1.254	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	NAXE →	+1.058	+1.216	<.001	.007	3	4
UPPER_AERODIGESTIVE_TRACT	GPI →	+0.858	+1.230	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	CHCHD3 →	+1.104	+1.263	<.001	.003	3	4
UPPER_AERODIGESTIVE_TRACT	SCP2 →	+0.915	+1.451	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016926 vs SKP1 — UPPER_AERODIGESTIVE_TRACT

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